Tesamorelin
Tesamorelin is a secretagogue studied for its ability to stimulate the body's own growth-hormone axis rather than introducing exogenous hormone. Research explores how pulsatile GH release influences recovery, body composition, and tissue maintenance via the GH/IGF-1 pathway.
Executive Summary
Tesamorelin is a secretagogue studied for its ability to stimulate the body's own growth-hormone axis rather than introducing exogenous hormone. Research explores how pulsatile GH release influences recovery, body composition, and tissue maintenance via the GH/IGF-1 pathway.
Research context: Tesamorelin is studied primarily within weight management and performance research. All information below is presented for educational and reference purposes only.
Discovery History
- 11970s–80s
Growth-hormone-releasing hormone (GHRH) and its fragments are characterized.
- 21990s
Synthetic GHRH analogs and ghrelin-mimetic secretagogues are developed.
- 32000s
Modifications (e.g. DAC technology) are engineered to extend half-life and prolong GH stimulation.
- 4Present
Secretagogues remain central to research on endogenous, pulsatile hormone signaling.
Mechanism of Action
GHRH / GHRP activity
Engages growth-hormone-releasing hormone or ghrelin receptors on the pituitary.
Pulsatile release
Studied for stimulating endogenous, pulsatile growth hormone secretion.
IGF-1 axis
Downstream elevation of IGF-1 explored for tissue and recovery signaling.
Feedback preservation
Investigated for maintaining physiological feedback loops of the GH axis.
Areas of Scientific Research
Body composition
Lean mass, adiposity, and recovery.
Sleep architecture
Deep sleep and nocturnal GH pulses.
Tissue repair
Collagen turnover and connective tissue.
Healthy aging
Age-related decline of the GH/IGF-1 axis.
Current Research
- 1
Preservation of physiological, pulsatile GH secretion versus exogenous hormone.
- 2
Downstream IGF-1 elevation and its role in tissue and recovery signaling.
- 3
Effects on sleep architecture and nocturnal GH pulses.
- 4
Body composition, lean mass, and age-related decline of the GH/IGF-1 axis.
Safety Information
For laboratory research use only — not for human or veterinary use.
Research use only
Tesamorelin is supplied strictly as a laboratory research reference material. It is not a drug, supplement, or food, and is not intended for human or veterinary use, consumption, or therapeutic application.
Handling
Handle with appropriate personal protective equipment in a controlled laboratory environment. Avoid inhalation, ingestion, and contact with skin or eyes.
Not clinically evaluated
Statements describe areas of scientific investigation only. No claims of safety or efficacy in humans are made or implied, and the compound has not been evaluated by regulatory agencies for any use.
Qualified personnel
Intended for use only by qualified researchers and institutions familiar with the proper handling of research reference materials.
Storage
Lyophilized (unopened)
Stable at room temperature for short periods; store at -20°C for long-term stability.
After reconstitution
Refrigerate at 2–8°C and use within 2–4 weeks depending on the compound.
Protect from light & heat
Avoid repeated freeze–thaw cycles and prolonged light exposure.
Handling
For laboratory research use only; handle with appropriate protective equipment.
Scientific References
- [1]
Sigalos JT, Pastuszak AW. The safety and efficacy of growth hormone secretagogues. Sexual Medicine Reviews, 2018.
- [2]
Teichman SL, et al. Prolonged stimulation of GH and IGF-1 secretion. JCEM, 2006.
- [3]
Walker RF. Sermorelin: a synthetic GHRH analog. Clinical Interventions in Aging, 2006.
References are provided for educational context and represent general areas of published literature on this class of compound.
Suggested Goals
Research objectives this compound is studied for.
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Read the scienceSource Tesamorelin for your research
Third-party tested reference material, from — per vial.